beta-Nicotinamide mononucleotide (NMN) CAS#1094-61-7

Nicotinamide ribotide, also known as NMN or beta-NMN, belongs to the class of organic compounds known as nicotinamide nucleotides. These are pyridine nucleotides, in which the pyridine base is nicotinamide or a derivative thereof. Nicotinamide ribotide is slightly soluble (in water) and a moderately acidic compound (based on its pKa). Nicotinamide ribotide has been found in human placenta tissue, and has also been detected in multiple biofluids, such as urine and blood. Within the cell, nicotinamide ribotide is primarily located in the cytoplasm, mitochondria and nucleus. Nicotinamide ribotide exists in all eukaryotes, ranging from yeast to humans. Nicotinamide ribotide participates in a number of enzymatic reactions. In particular, Nicotinamide ribotide can be biosynthesized from nicotinamide riboside; which is catalyzed by the enzyme cytosolic purine 5′-nucleotidase. Furthermore, Nicotinamide ribotide can be biosynthesized from niacinamide and phosphoribosyl pyrophosphate; which is catalyzed by the enzyme nicotinamidephosphoribosyltransferase. Furthermore, Nicotinamide ribotide can be biosynthesized from nicotinamide riboside through the action of the enzyme nicotinamide riboside kinase. Finally, Nicotinamide ribotide can be converted into NAD; which is catalyzed by the enzyme nicotinamide/nicotinic acid mononucleotide adenylyltransferase. In humans, nicotinamide ribotide is involved in the nicotinate and nicotinamide metabolism pathway.